Examining kinesin processivity within a general gating framework

Examining kinesin processivity within a general gating framework

Kinesin-1 is a dimeric motor that transports cargo along microtubules, taking 8.2-nm steps in a hand-over-hand fashion. The ATP hydrolysis cycles of its two heads are maintained out of phase by a series of gating mechanisms, which lead to processive runs averaging ∼1 μm. A key structural element for...

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Bibliographic Details
Main Authors: Johan OL Andreasson, Bojan Milic, Geng-Yuan Chen, Nicholas R Guydosh, William O Hancock, Steven M Block
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-04-01
Series:eLife
Subjects:
optical trap
molecular motor
single molecule
Online Access:https://elifesciences.org/articles/07403

Internet

https://elifesciences.org/articles/07403

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