Selective inhibition of soluble tumor necrosis factor signaling reduces abdominal aortic aneurysm progression

Selective inhibition of soluble tumor necrosis factor signaling reduces abdominal aortic aneurysm progression

BackgroundTumor necrosis factor (TNF) is pathologically elevated in human abdominal aortic aneurysms (AAA). Non-selective TNF inhibition-based therapeutics are approved for human use but have been linked to several side effects. Compounds that target the proinflammatory soluble form of TNF (solTNF)...

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Bibliographic Details
Main Authors: Silke Griepke, Emilie Grupe, Jes Sanddal Lindholt, Elizabeth Hvitfeldt Fuglsang, Lasse Bach Steffensen, Hans Christian Beck, Mia Dupont Larsen, Sissel Karoline Bang-Møller, Martin Overgaard, Lars Melholt Rasmussen, Kate Lykke Lambertsen, Jane Stubbe
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiovascular disease
abdominal aortic aneurysm
tumor necrosis factor inhibitor
inflammation
translational research
vascular inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.942342/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.942342/full

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