1,4-Disubstituted Thiosemicarbazide Derivatives are Potent Inhibitors of Toxoplasma gondii Proliferation

1,4-Disubstituted Thiosemicarbazide Derivatives are Potent Inhibitors of Toxoplasma gondii Proliferation

A series of 4-arylthiosemicarbazides substituted at the N1 position with a 5-membered heteroaryl ring was synthesized and evaluated in vitro for T. gondii inhibition proliferation and host cell cytotoxicity. At non-toxic concentrations for the host cells all studied compounds displayed excellent an...

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Bibliographic Details
Main Authors: Katarzyna Dzitko, Agata Paneth, Tomasz Plech, Jakub Pawełczyk, Paweł Stączek, Joanna Stefańska, Piotr Paneth
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Molecules
Subjects:
thiosemicarbazide derivatives
anti-Toxoplasma gondii activity
antibacterial activity
bacterial topoisomerases
toxicity
docking studies
DFT calculations
Online Access:http://www.mdpi.com/1420-3049/19/7/9926

Internet

http://www.mdpi.com/1420-3049/19/7/9926

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