Connecting a disconnected trial network with a new trial: optimizing the estimation of a comparative effect in a network meta-analysis

Abstract Background In network meta-analysis, estimation of a comparative effect can be performed for treatments that are connected either directly or indirectly. However, disconnected trial networks may arise, which poses a challenge to comparing all available treatments of interest. Several modeli...

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Bibliographic Details
Main Authors: Lauren McKeen, Paul Morris, Chong Wang, Max D. Morris, Annette M. O’Connor
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:https://doi.org/10.1186/s12874-023-01896-7