Allyl isothiocyanate (AITC) activates nonselective cation currents in human cardiac fibroblasts: possible involvement of TRPA1

Allyl isothiocyanate (AITC) activates nonselective cation currents in human cardiac fibroblasts: possible involvement of TRPA1

The effects of allyl isothiocyanate (AITC), transient receptor potential ankyrin 1 (TRPA1) agonist, on cultured human cardiac fibroblasts were examined by measuring intracellular Ca2+ concentration [Ca2+]i and whole-cell voltage clamp techniques. AITC (200 μM) increased Ca2+ entry in the presence of...

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Bibliographic Details
Main Authors: Gaku Oguri, Toshiaki Nakajima, Hironobu Kikuchi, Shotaro Obi, Fumitaka Nakamura, Issei Komuro
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Heliyon
Subjects:
Human cardiac fibroblast
Transient receptor potential ankyrin 1
TRPA1
Allyl isothiocyanate
Methylglyoxal
Nonselective cation channels
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020326591

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http://www.sciencedirect.com/science/article/pii/S2405844020326591

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