Hippocampal protein expression is differentially affected by chronic paroxetine treatment in adolescent and adult rats: A possible mechanism of paradoxical antidepressant responses in young persons

Selective serotonin reuptake inhibitors (SSRIs) are commonly recognised as the pharmacological treatment of choice for patients with depressive disorders, yet their use in adolescent populations has come under scrutiny following reports of minimal efficacy and an increased risk of suicidal ideation...

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Bibliographic Details
Main Authors: Emily Aspasia Karanges, Mohammed A Kashem, Ranjana eSarker, Eakhlas U Ahmed, Selina eAhmed, Petra evan Nieuwenhuijzen, Andrew H Kemp, Iain S McGregor
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00086/full