Paeoniflorin shows chondroprotective effects under IL-1β stress by regulating circ-PREX1/miR-140-3p/WNT5B axis

Paeoniflorin shows chondroprotective effects under IL-1β stress by regulating circ-PREX1/miR-140-3p/WNT5B axis

Abstract Background Osteoarthritis (OA) is a chronic and degenerative bone and joint disease, and paeoniflorin shows anti-arthritis role in OA. This study planned to investigate the mechanism related to chondroprotective role of paeoniflorin in OA. Methods Real-time quantitative PCR and western blot...

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Bibliographic Details
Main Authors: Lan’e Wu, Runke Tang, Weibiao Xiong, Shuhua Song, Qian Guo, Qingqing Zhang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Paeoniflorin
KOA
Chondrocytes
Circ-PREX1
miR-140-3p
WNT5B
Online Access:https://doi.org/10.1186/s13018-023-04238-x

Internet

https://doi.org/10.1186/s13018-023-04238-x

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