Mitf regulates gene expression networks implicated in B cell homeostasis, germinal center responses, and tolerance

Mitf regulates gene expression networks implicated in B cell homeostasis, germinal center responses, and tolerance

IntroductionThe microphthalmia transcription factor Mitf has been shown to regulate B cell activation and tolerance. However, the underlying B cell-specific mechanisms responsible, and those that distinguish Mitf from closely related Mitf/TFE (MiT) transcription factors Tfe3, Tfeb, and Tfec, remain...

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Main Authors: Abhimanyu Amarnani, Maria Lopez-Ocasio, Ramile Dilshat, Kamala Anumukonda, Jonathan Davila, Nikita Malakhov, Chongmin Huan, Erna Magnusdottir, Eirikur Steingrimsson, Christopher A. Roman
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
B lymphocyte
tolerance
germinal center
transcriptome
microphthalmia transcription factor (Mitf)
type-I-interferon
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1339325/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1339325/full

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