Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na<sup>+</sup>,K<sup>+</sup>-ATPase α<sub>2</sub>-Isoform

Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na<sup>+</sup>,K<sup>+</sup>-ATPase α<sub>2</sub>-Isoform

Two α-isoforms of the Na<sup>+</sup>,K<sup>+</sup>-ATPase (α<sub>1</sub> and α<sub>2</sub>) are expressed in the cardiovascular system, and it is unclear which isoform is the preferential regulator of contractility. Mice heterozygous for the familial h...

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Bibliographic Details
Main Authors: Rajkumar Rajanathan, Clàudia Vilaseca i Riera, Tina Myhre Pedersen, Christian Staehr, Elena V. Bouzinova, Jens Randel Nyengaard, Morten B. Thomsen, Hans Erik Bøtker, Vladimir V. Matchkov
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
Na<sup>+</sup>,K<sup>+</sup>-ATPase
α<sub>2</sub>-isoform
contractility
relaxation
ouabain
Langendorff
Online Access:https://www.mdpi.com/2073-4409/12/8/1108

Internet

https://www.mdpi.com/2073-4409/12/8/1108

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