A Single LC-MS/MS Analysis to Quantify CoA Biosynthetic Intermediates and Short-Chain Acyl CoAs

A Single LC-MS/MS Analysis to Quantify CoA Biosynthetic Intermediates and Short-Chain Acyl CoAs

Coenzyme A (CoA) is an essential cofactor for dozens of reactions in intermediary metabolism. Dysregulation of CoA synthesis or acyl CoA metabolism can result in metabolic or neurodegenerative disease. Although several methods use liquid chromatography coupled with mass spectrometry/mass spectrometr...

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Bibliographic Details
Main Authors: Anthony E. Jones, Nataly J. Arias, Aracely Acevedo, Srinivasa T. Reddy, Ajit S. Divakaruni, David Meriwether
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Metabolites
Subjects:
LC-MS/MS
CoA biosynthesis
short-chain acyl CoAs
mitochondria
etomoxir
Online Access:https://www.mdpi.com/2218-1989/11/8/468

Internet

https://www.mdpi.com/2218-1989/11/8/468

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