The Metalloprotease-Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its Aggressiveness

The Metalloprotease-Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its Aggressiveness

Glioblastoma (GBM) as the most common and aggressive brain tumor is characterized by genetic heterogeneity, invasiveness, radio-/chemoresistance, and occurrence of GBM stem-like cells. The metalloprotease-disintegrin ADAM8 is highly expressed in GBM tumor and immune cells and correlates with poor su...

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Bibliographic Details
Main Authors: Agnes Schäfer, Lara Evers, Lara Meier, Uwe Schlomann, Miriam H. A. Bopp, Gian-Luca Dreizner, Olivia Lassmann, Aaron Ben Bacha, Andreea-Cristina Benescu, Mirza Pojskic, Christian Preußer, Elke Pogge von Strandmann, Barbara Carl, Christopher Nimsky, Jörg W. Bartsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
tumor microenvironment
extracellular vesicles
miRNA
MR spectroscopy
ADAM8
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.826273/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.826273/full

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