Mus musculus papillomavirus 1 E8^E2 represses expression of late protein E4 in basal-like keratinocytes via NCoR/SMRT-HDAC3 co-repressor complexes to enable wart formation in vivo

Mus musculus papillomavirus 1 E8^E2 represses expression of late protein E4 in basal-like keratinocytes via NCoR/SMRT-HDAC3 co-repressor complexes to enable wart formation in vivo

ABSTRACT High-risk human papillomaviruses (PV) account for approximately 600,000 new cancers per year. The early protein E8^E2 is a conserved repressor of PV replication, whereas E4 is a late protein that arrests cells in G2 and collapses keratin filaments to facilitate virion release. While inactiv...

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Bibliographic Details
Main Authors: Franziska Kuehner, Margaret Wong, Elke Straub, John Doorbar, Thomas Iftner, Richard B. S. Roden, Frank Stubenrauch
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
papillomavirus
E8^E2
E4
wart
productive replication
Online Access:https://journals.asm.org/doi/10.1128/mbio.00696-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00696-23

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