Multidimensional analysis of behavior predicts genotype with high accuracy in a mouse model of Angelman syndrome

Abstract Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of expression of the maternal copy of the UBE3A gene. Individuals with AS have a multifaceted behavioral phenotype consisting of deficits in motor function, epilepsy, cognitive impairment, sleep abnormalities, as well as...

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Bibliographic Details
Main Authors: Joseph K. Tanas, Devante D. Kerr, Li Wang, Anika Rai, Ilse Wallaard, Ype Elgersma, Michael S. Sidorov
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-02206-3