Extracellular vesicle‐mediated delivery of CRISPR/Cas9 ribonucleoprotein complex targeting proprotein convertase subtilisin‐kexin type 9 (Pcsk9) in primary mouse hepatocytes

Extracellular vesicle‐mediated delivery of CRISPR/Cas9 ribonucleoprotein complex targeting proprotein convertase subtilisin‐kexin type 9 (Pcsk9) in primary mouse hepatocytes

Abstract The loss‐of‐function of the proprotein convertase subtilisin–kexin type 9 (Pcsk9) gene has been associated with significant reductions in plasma serum low‐density lipoprotein cholesterol (LDL‐C) levels. Both CRISPR/Cas9 and CRISPR‐based editor‐mediated Pcsk9 inactivation have successfully l...

Full description

Bibliographic Details
Main Authors: Nazma F. Ilahibaks, Thomas A. Kluiver, Olivier G. deJong, Saskia C. A. deJager, Raymond M. Schiffelers, Pieter Vader, Weng Chuan Peng, Zhiyong Lei, Joost P. G. Sluijter
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Journal of Extracellular Vesicles
Subjects:
cholesterol‐lowering therapy
CRISPR/Cas9 delivery
exosomes
extracellular vesicles
gene therapy
increased LDL‐C uptake
Online Access:https://doi.org/10.1002/jev2.12389

Internet

https://doi.org/10.1002/jev2.12389

Similar Items