Core and shell platelets of a thrombus: A new microfluidic assay to study mechanics and biochemistry

Abstract Background Hemostatic clots have a P‐selectin positive platelet core covered with a shell of P‐selectin negative platelets. Objective To develop a new human blood microfluidic assay to interrogate core/shell mechanics. Methods A 2‐stage assay perfused whole blood over collagen/± tissue fact...

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Bibliographic Details
Main Authors: Michael E. DeCortin, Lawrence F. Brass, Scott L. Diamond
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
Online Access:https://doi.org/10.1002/rth2.12405