Luteolin-rich fraction from Perilla frutescens seed meal inhibits spike glycoprotein S1 of SARS-CoV-2-induced NLRP3 inflammasome lung cell inflammation via regulation of JAK1/STAT3 pathway: A potential anti-inflammatory compound against inflammation-induced long-COVID

Luteolin-rich fraction from Perilla frutescens seed meal inhibits spike glycoprotein S1 of SARS-CoV-2-induced NLRP3 inflammasome lung cell inflammation via regulation of JAK1/STAT3 pathway: A potential anti-inflammatory compound against inflammation-induced long-COVID

ObjectiveThe multi-systemic inflammation as a result of COVID-19 can persevere long after the initial symptoms of the illness have subsided. These effects are referred to as Long-COVID. Our research focused on the contribution of the Spike protein S1 subunit of SARS-CoV-2 (Spike S1) on the lung infl...

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Bibliographic Details
Main Authors: Sivamoke Dissook, Sonthaya Umsumarng, Sariya Mapoung, Warathit Semmarath, Punnida Arjsri, Kamonwan Srisawad, Pornngarm Dejkriengkraikul
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Medicine
Subjects:
Perilla frutescens extract
luteolin (Lu)
spike glycoprotein S1
long-COVID
anti-inflammation
lung inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.1072056/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.1072056/full

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