GM1 Oligosaccharide Crosses the Human Blood–Brain Barrier In Vitro by a Paracellular Route

GM1 Oligosaccharide Crosses the Human Blood–Brain Barrier In Vitro by a Paracellular Route

Ganglioside GM1 (GM1) has been reported to functionally recover degenerated nervous system in vitro and in vivo, but the possibility to translate GM1′s potential in clinical settings is counteracted by its low ability to overcome the blood–brain barrier (BBB) due to its amphiphilic nature. Interesti...

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Bibliographic Details
Main Authors: Erika Di Biase, Giulia Lunghi, Margherita Maggioni, Maria Fazzari, Diego Yuri Pomè, Nicoletta Loberto, Maria Grazia Ciampa, Pamela Fato, Laura Mauri, Emmanuel Sevin, Fabien Gosselet, Sandro Sonnino, Elena Chiricozzi
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
ganglioside GM1
GM1-oligosaccharide
blood–brain barrier
brain-like endothelial cells
drug discovery
neurodegeneration
Online Access:https://www.mdpi.com/1422-0067/21/8/2858

Internet

https://www.mdpi.com/1422-0067/21/8/2858

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