Steroidal Triterpenes: Design of Substrate-Based Inhibitors of Ergosterol and Sitosterol Synthesis

This article reviews the design and study, in our own laboratory and others, of new steroidal triterpenes with a modified lanosterol or cycloartenol frame. These compounds, along with a number of known analogs with the cholestane skeleton, have been evaluated as reversible or irreversible inhibitors...

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Bibliographic Details
Main Authors: Jialin Liu, William David Nes
Format: Article
Language:English
Published: MDPI AG 2009-11-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/14/11/4690/