Intrinsic Bio-Signature of Gene Delivery Nanocarriers May Impair Gene Therapy Goals
Non-viral lipid/polymeric vectors have widely been used as nanocarriers (NCs) for gene delivery. They possess large surface area to volume ratio and are able to interact with biomolecules through functional moieties, resulting in inadvertent biological impacts, in particular at genomic level. Thus,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2013-09-01
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| Series: | BioImpacts |
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| Online Access: | http://dx.doi.org/10.5681/bi.2013.028 |
| _version_ | 1818808845171949568 |
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| author | Jaleh Barar Yadollah Omidi |
| author_facet | Jaleh Barar Yadollah Omidi |
| author_sort | Jaleh Barar |
| collection | DOAJ |
| description | Non-viral lipid/polymeric vectors have widely been used as nanocarriers (NCs) for gene delivery. They possess large surface area to volume ratio and are able to interact with biomolecules through functional moieties, resulting in inadvertent biological impacts, in particular at genomic level. Thus, their genomic bio-signature needs to be investigated prior to use in vivo. Using high-throughput microarray and qPCR gene expression profiling techniques, we have reported the genomic impacts of lipid/polymeric NCs. Given the fact that the ultimate objectives of gene therapy may inevitably be impaired by nonspecific intrinsic genomic impacts of these NCs, here, we highlight their nonspecific genomic bio-signature. We envision that better understanding on the genotoxicity of gene delivery NCs, as guiding premise, will help us to develop much safer NCs and also to accelerate their translation into clinical use and to provide pivotal information on safety liabilities early in discovery and developments process prior to its inevitable consequences in vivo. |
| first_indexed | 2024-12-18T19:48:02Z |
| format | Article |
| id | doaj.art-83dce4f1410241f98eb0ce309c4fd26e |
| institution | Directory Open Access Journal |
| issn | 2228-5652 2228-5660 |
| language | English |
| last_indexed | 2024-12-18T19:48:02Z |
| publishDate | 2013-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | BioImpacts |
| spelling | doaj.art-83dce4f1410241f98eb0ce309c4fd26e2022-12-21T20:55:16ZengTabriz University of Medical SciencesBioImpacts2228-56522228-56602013-09-013310510910.5681/bi.2013.028Intrinsic Bio-Signature of Gene Delivery Nanocarriers May Impair Gene Therapy GoalsJaleh BararYadollah OmidiNon-viral lipid/polymeric vectors have widely been used as nanocarriers (NCs) for gene delivery. They possess large surface area to volume ratio and are able to interact with biomolecules through functional moieties, resulting in inadvertent biological impacts, in particular at genomic level. Thus, their genomic bio-signature needs to be investigated prior to use in vivo. Using high-throughput microarray and qPCR gene expression profiling techniques, we have reported the genomic impacts of lipid/polymeric NCs. Given the fact that the ultimate objectives of gene therapy may inevitably be impaired by nonspecific intrinsic genomic impacts of these NCs, here, we highlight their nonspecific genomic bio-signature. We envision that better understanding on the genotoxicity of gene delivery NCs, as guiding premise, will help us to develop much safer NCs and also to accelerate their translation into clinical use and to provide pivotal information on safety liabilities early in discovery and developments process prior to its inevitable consequences in vivo.http://dx.doi.org/10.5681/bi.2013.028Gene DeliveryGene TherapyGenotoxicityMicroarrayNanotoxicologyToxicogenomics |
| spellingShingle | Jaleh Barar Yadollah Omidi Intrinsic Bio-Signature of Gene Delivery Nanocarriers May Impair Gene Therapy Goals BioImpacts Gene Delivery Gene Therapy Genotoxicity Microarray Nanotoxicology Toxicogenomics |
| title | Intrinsic Bio-Signature of Gene Delivery Nanocarriers May Impair Gene Therapy Goals |
| title_full | Intrinsic Bio-Signature of Gene Delivery Nanocarriers May Impair Gene Therapy Goals |
| title_fullStr | Intrinsic Bio-Signature of Gene Delivery Nanocarriers May Impair Gene Therapy Goals |
| title_full_unstemmed | Intrinsic Bio-Signature of Gene Delivery Nanocarriers May Impair Gene Therapy Goals |
| title_short | Intrinsic Bio-Signature of Gene Delivery Nanocarriers May Impair Gene Therapy Goals |
| title_sort | intrinsic bio signature of gene delivery nanocarriers may impair gene therapy goals |
| topic | Gene Delivery Gene Therapy Genotoxicity Microarray Nanotoxicology Toxicogenomics |
| url | http://dx.doi.org/10.5681/bi.2013.028 |
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