Distinct effects of IPSU and suvorexant on mouse sleep architecture

Distinct effects of IPSU and suvorexant on mouse sleep architecture

Dual orexin receptor (OXR) antagonists (DORAs) such as almorexant, SB-649868, suvorexant (MK-4305) and filorexant (MK-6096), have shown promise for the treatment of insomnias and sleep disorders. Whether antagonism of both OX1R and OX2R is necessary for sleep induction has been a matter of some deb...

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Bibliographic Details
Main Authors: Daniel eHoyer, Thomas eDürst, Markus eFendt, Laura H Jacobson, Claudia eBetschart, Samuel eHintermann, Dirk eBehnke, Simona eCotesta, Grit eLaue, Silvio eOfner, Eric eLegangneux, Christine E Gee
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Neuroscience
Subjects:
Pharmacology
insomnia
orexin receptor antagonist
REM and NREM sleep
mouse sleep
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00235/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00235/full

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