Losartan Inhibits Nuclear Factor-κB Activation Induced by Small, Dense LDL Cholesterol Particles in Human Umbilical Vein Endothelial Cells

Losartan Inhibits Nuclear Factor-κB Activation Induced by Small, Dense LDL Cholesterol Particles in Human Umbilical Vein Endothelial Cells

Objective: We aimed to investigate how losartan exerts protective effects on human umbilical vein endothelial cell injury induced by small, dense, LDL (sLDL) cholesterol particles. Methods: sLDL cholesterol was isolated by a 2-steps method and the nuclear translocation and activation of nuclear fact...

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Bibliographic Details
Main Authors: Gonghui Guo, MM, Xiaojing Cheng, MM, Rong Fu, MM
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Current Therapeutic Research
Subjects:
losartan
nuclear factor-κB
small, dense, LDL
Online Access:http://www.sciencedirect.com/science/article/pii/S0011393X13000374

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http://www.sciencedirect.com/science/article/pii/S0011393X13000374

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