Protease-Independent Production of Poliovirus Virus-like Particles in Pichia pastoris: Implications for Efficient Vaccine Development and Insights into Capsid Assembly

Protease-Independent Production of Poliovirus Virus-like Particles in Pichia pastoris: Implications for Efficient Vaccine Development and Insights into Capsid Assembly

ABSTRACT The production of enterovirus virus-like particles (VLPs) that lack the viral genome have great potential as vaccines for a number of diseases, such as poliomyelitis and hand, foot, and mouth disease. These VLPs can mimic empty capsids, which are antigenically indistinguishable from mature...

Full description

Bibliographic Details
Main Authors: Lee Sherry, Jessica J. Swanson, Keith Grehan, Huijun Xu, Mai Uchida, Ian M. Jones, Nicola J. Stonehouse, David J. Rowlands
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
poliovirus
vaccine
virus-like particle
Pichia pastoris
poliomyelitis
vaccines
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04300-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.04300-22

Similar Items