Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger

Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger

Abstract Pendrin (SLC26A4) is an anion exchanger expressed in the apical membranes of selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder associated with sensorineural hearing loss, hypothyroid goiter, and reduced blood pressure. However its molecular structure has remai...

Full description

Bibliographic Details
Main Authors: Qianying Liu, Xiang Zhang, Hui Huang, Yuxin Chen, Fang Wang, Aihua Hao, Wuqiang Zhan, Qiyu Mao, Yuxia Hu, Lin Han, Yifang Sun, Meng Zhang, Zhimin Liu, Geng-Lin Li, Weijia Zhang, Yilai Shu, Lei Sun, Zhenguo Chen
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38303-0

Internet

https://doi.org/10.1038/s41467-023-38303-0

Similar Items