Pharmacokinetic/Pharmacodynamic (PK/PD) Simulation for Dosage Optimization of Colistin Against Carbapenem-Resistant <i>Klebsiella pneumoniae</i> and Carbapenem-Resistant <i>Escherichia coli</i>

Pharmacokinetic/Pharmacodynamic (PK/PD) Simulation for Dosage Optimization of Colistin Against Carbapenem-Resistant <i>Klebsiella pneumoniae</i> and Carbapenem-Resistant <i>Escherichia coli</i>

The purpose was to explore the optimal dosage regimen of colistin using Monte Carlo simulations, for the treatment of carbapenem-resistant <i>Klebsiella pneumoniae</i> and carbapenem-resistant <i>Escherichia coli</i> based on PK/PD targets in critically ill patients. A total...

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Bibliographic Details
Main Authors: Kamonchanok Jitaree, Korbtham Sathirakul, Jantana Houngsaitong, Orarik Asuphon, Weerayuth Saelim, Visanu Thamlikitkul, Preecha Montakantikul
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Antibiotics
Subjects:
colistin
Monte Carlo simulation
pharmacokinetics
pharmacodynamics
carbapenem-resistant <i>Klebsiella</i> <i>pneumoniae</i>
carbapenem-resistant <i>Escherichia coli</i>
Online Access:https://www.mdpi.com/2079-6382/8/3/125

Internet

https://www.mdpi.com/2079-6382/8/3/125

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