38766 Massively Parallel Reporter Assay Reveals Functional Impact of 3™-UTR SNPs Associated with Neurological and Psychiatric Disorders
ABSTRACT IMPACT: Screening the effect of thousands of non-coding genetic variants will help identify variants important in the etiology of diseases OBJECTIVES/GOALS: Massively parallel reporter assays (MPRAs) can experimentally evaluate the impact of genetic variants on gene expression. In this stud...
Main Authors: | Andy B. Chen, Kriti Thapa, Hongyu Gao, Jill L. Reiter, Junjie Zhang, Xiaoling Xuei, Hongmei Gu, Yue Wang, Howard J. Edenberg, Yunlong Liu |
---|---|
Format: | Article |
Language: | English |
Published: |
Cambridge University Press
2021-03-01
|
Series: | Journal of Clinical and Translational Science |
Online Access: | https://www.cambridge.org/core/product/identifier/S2059866121006452/type/journal_article |
Similar Items
-
Systematic identification of functional SNPs interrupting 3'UTR polyadenylation signals.
by: Eldad David Shulman, et al.
Published: (2020-08-01) -
Mining the 3′UTR of Autism-implicated Genes for SNPs Perturbing MicroRNA Regulation
by: Varadharajan Vaishnavi, et al.
Published: (2014-04-01) -
Functional classes of SNPs related to psychiatric disorders and behavioral traits contrast with those related to neurological disorders.
by: Mark A Reimers, et al.
Published: (2024-01-01) -
Impact of the interaction between 3’-UTR SNPs and microRNA on the expression of human xenobiotic metabolism enzyme and transporter (XMETs) genes
by: Rongrong eWei, et al.
Published: (2012-11-01) -
Two novel SNPs in ATXN3 3' UTR may decrease age at onset of SCA3/MJD in Chinese patients.
by: Zhe Long, et al.
Published: (2015-01-01)