CTNNB1 signaling in sertoli cells downregulates spermatogonial stem cell activity via WNT4.

CTNNB1 signaling in sertoli cells downregulates spermatogonial stem cell activity via WNT4.

Constitutive activation of the WNT signaling effector CTNNB1 (β-catenin) in the Sertoli cells of the Ctnnb1(tm1Mmt/+);Amhr2(tm3(cre)Bhr/+) mouse model results in progressive germ cell loss and sterility. In this study, we sought to determine if this phenotype could be due to a loss of spermatogonial...

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Bibliographic Details
Main Authors: Alexandre Boyer, Jonathan R Yeh, Xiangfan Zhang, Marilène Paquet, Aurore Gaudin, Makoto C Nagano, Derek Boerboom
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3257228?pdf=render

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http://europepmc.org/articles/PMC3257228?pdf=render

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