Design, Synthesis and Biological Evaluation of Novel and Potent Protein Arginine Methyltransferases 5 Inhibitors for Cancer Therapy

Design, Synthesis and Biological Evaluation of Novel and Potent Protein Arginine Methyltransferases 5 Inhibitors for Cancer Therapy

Protein arginine methyltransferases 5 (PRMT5) is a clinically promising epigenetic target that is upregulated in a variety of tumors. Currently, there are several PRMT5 inhibitors under preclinical or clinical development, however the established clinical inhibitors show favorable toxicity. Thus, it...

Full description

Bibliographic Details
Main Authors: Yixuan Tang, Shihui Huang, Xingxing Chen, Junzhang Huang, Qianwen Lin, Lei Huang, Shuping Wang, Qihua Zhu, Yungen Xu, Yi Zou
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
epigenetic
PRMT5 inhibitors
THIQ
cancer
Online Access:https://www.mdpi.com/1420-3049/27/19/6637

Internet

https://www.mdpi.com/1420-3049/27/19/6637

Similar Items