A benchmark of algorithms for the analysis of pooled CRISPR screens

A benchmark of algorithms for the analysis of pooled CRISPR screens

Abstract Genome-wide pooled CRISPR-Cas-mediated knockout, activation, and repression screens are powerful tools for functional genomic investigations. Despite their increasing importance, there is currently little guidance on how to design and analyze CRISPR-pooled screens. Here, we provide a review...

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Bibliographic Details
Main Authors: Sunil Bodapati, Timothy P. Daley, Xueqiu Lin, James Zou, Lei S. Qi
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Genome Biology
Subjects:
CRISPR screen
CRISPR knockoout
CRISPR interference
CRISPR activation
Benchmarking
Screen algorithms
Online Access:http://link.springer.com/article/10.1186/s13059-020-01972-x

Internet

http://link.springer.com/article/10.1186/s13059-020-01972-x

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