Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration

Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration

Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone formation through phosphorylation of serine 14 (S1...

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Bibliographic Details
Main Authors: Hyo Rim Ko, Il-Sun Kwon, Inwoo Hwang, Eun-Ju Jin, Joo-Ho Shin, Angela M Brennan-Minnella, Raymond Swanson, Sung-Woo Cho, Kyung-Hoon Lee, Jee-Yin Ahn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
axon growth
AKT
Id2
growth cone
developing neuron
axon regeneration
Online Access:https://elifesciences.org/articles/20799

Internet

https://elifesciences.org/articles/20799

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