The state of the art in the treatment of severe aplastic anemia: immunotherapy and hematopoietic cell transplantation in children and adults

The state of the art in the treatment of severe aplastic anemia: immunotherapy and hematopoietic cell transplantation in children and adults

Acquired aplastic anemia (AA) is an immune-mediated bone marrow (BM) failure where marrow disruption is driven by a cytotoxic T-cell–mediated autoimmune attack against hematopoietic stem cells. The key diagnostic challenge in children, but also in adults, is to exclude the possible underlying congen...

Full description

Bibliographic Details
Main Authors: Agnieszka Piekarska, Katarzyna Pawelec, Anna Szmigielska-Kapłon, Marek Ussowicz
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
aplastic anemia
antithymocyte globulin
eltrombopag
hATG
hematopoietic cell transplantation
immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1378432/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1378432/full

Similar Items