Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis

Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis

Abstract Deletion of phenylalanine 508 of the cystic fibrosis transmembrane conductance regulator (ΔF508 CFTR) is a major cause of cystic fibrosis (CF), one of the most common inherited childhood diseases. ΔF508 CFTR is a trafficking mutant that is retained in the endoplasmic reticulum (ER) and unab...

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Bibliographic Details
Main Authors: R. Reilly, M. S. Mroz, E. Dempsey, K. Wynne, S. J. Keely, E. F. McKone, C. Hiebel, C. Behl, J. A. Coppinger
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-06588-z

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https://doi.org/10.1038/s41598-017-06588-z

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