Design and evaluation of magnetic-targeted bilosomal gel for rheumatoid arthritis: flurbiprofen delivery using superparamagnetic iron oxide nanoparticles

Design and evaluation of magnetic-targeted bilosomal gel for rheumatoid arthritis: flurbiprofen delivery using superparamagnetic iron oxide nanoparticles

IntroductionThe study aimed to systematically enhance the fabrication process of flurbiprofen-loaded bilosomes (FSB) using Quality by Design (QbD) principles and Design of Experiments (DOE). The objective was to develop an optimized formulation with improved entrapment efficiency and targeted drug d...

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Bibliographic Details
Main Authors: Rayan Y. Mushtaq, Nimbagal Raghavendra Naveen, Krishna Jayanth Rolla, Humood Al Shmrany, Sameer Alshehri, Ahmad Salawi, Mallesh Kurakula, Majed A. Alghamdi, Waleed Y. Rizg, Rana B. Bakhaidar, Walaa A. Abualsunun, Khaled M. Hosny, Abdulmohsin J. Alamoudi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Pharmacology
Subjects:
quality by design
design of experiments
flubiprofen-loaded bilosomes
superparamagnetic iron oxide nanoparticles
targeted drug delivery
osteoarthritis management
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1433734/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1433734/full

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