Targeting the Pseudomonas aeruginosa Virulence Factor Phospholipase C With Engineered Liposomes

Targeting the Pseudomonas aeruginosa Virulence Factor Phospholipase C With Engineered Liposomes

Engineered liposomes composed of the naturally occurring lipids sphingomyelin (Sm) and cholesterol (Ch) have been demonstrated to efficiently neutralize toxins secreted by Gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus. Here, we hypothesized that liposomes are capa...

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Bibliographic Details
Main Authors: Heidi Wolfmeier, Samuel J. T. Wardell, Leo T. Liu, Reza Falsafi, Annette Draeger, Eduard B. Babiychuk, Daniel Pletzer, Robert E. W. Hancock
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Microbiology
Subjects:
cholesterol
sphingomyelin
plcH
abscess
dermonecrosis
anti-virulence
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.867449/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.867449/full

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