Functional Characterization of Glycoprotein Nonmetastatic Melanoma Protein B in Scleroderma Fibrosis

Functional Characterization of Glycoprotein Nonmetastatic Melanoma Protein B in Scleroderma Fibrosis

Glycoprotein nonmetastatic melanoma protein B (GPNMB) is involved in various cell functions such as cell adhesion, migration, proliferation, and differentiation. In this study, we set forth to determine the role of GPNMB in systemic sclerosis (SSc) fibroblasts. Dermal fibroblasts were isolated from...

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Bibliographic Details
Main Authors: Pamela J. Palisoc, Leah Vaikutis, Mikel Gurrea-Rubio, Ellen N. Model, Morgan M. O’mara, Sarah Ory, Sirapa Vichaikul, Dinesh Khanna, Pei-Suen Tsou, Amr H. Sawalha
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
scleroderma
fibrosis
dermal fibroblasts
GPNMB
autoimmunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.814533/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.814533/full

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