Pyrophosphate Stimulates the Phosphate-Sodium Symporter of <italic toggle="yes">Trypanosoma brucei</italic> Acidocalcisomes and <italic toggle="yes">Saccharomyces cerevisiae</italic> Vacuoles

Pyrophosphate Stimulates the Phosphate-Sodium Symporter of <italic toggle="yes">Trypanosoma brucei</italic> Acidocalcisomes and <italic toggle="yes">Saccharomyces cerevisiae</italic> Vacuoles

ABSTRACT Inorganic pyrophosphate (PPi) is a by-product of biosynthetic reactions and has bioenergetic and regulatory roles in a variety of cells. Here we show that PPi and other pyrophosphate-containing compounds, including polyphosphate (polyP), can stimulate sodium-dependent depolarization of the...

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Bibliographic Details
Main Authors: Evgeniy Potapenko, Ciro D. Cordeiro, Guozhong Huang, Roberto Docampo
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mSphere
Subjects:
SPX domain
Saccharomyces cerevisiae
Trypanosoma brucei
Xenopus laevis
acidocalcisome
phosphate-sodium symporter
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00045-19

Internet

https://journals.asm.org/doi/10.1128/mSphere.00045-19

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