EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

Polycomb Repressive Complex 2 (PRC2) plays critical roles in transcriptional silencing during development. Here the authors identify EZHIP as a cofactor of PRC2 expressed predominantly in the gonads, finding that EZHIP limits the enzymatic activity of PRC2 in germ cells in mice.

Bibliographic Details
Main Authors: Roberta Ragazzini, Raquel Pérez-Palacios, Irem H. Baymaz, Seynabou Diop, Katia Ancelin, Dina Zielinski, Audrey Michaud, Maëlle Givelet, Mate Borsos, Setareh Aflaki, Patricia Legoix, Pascal W. T. C. Jansen, Nicolas Servant, Maria-Elena Torres-Padilla, Deborah Bourc’his, Pierre Fouchet, Michiel Vermeulen, Raphaël Margueron
Format: Article
Language:English
Published: Nature Portfolio 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11800-x

Internet

https://doi.org/10.1038/s41467-019-11800-x

Similar Items