ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma

ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma

Cell proliferation requires the orchestrated actions of a myriad of proteins regulating DNA replication, DNA repair and damage tolerance, and cell cycle. Proliferating cell nuclear antigen (PCNA) is a master regulator which interacts with multiple proteins functioning in these processes, and this ma...

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Bibliographic Details
Main Authors: Giovanni Luca Gravina, Alessandro Colapietro, Andrea Mancini, Alessandra Rossetti, Stefano Martellucci, Luca Ventura, Martina Di Franco, Francesco Marampon, Vincenzo Mattei, Leda Assunta Biordi, Marit Otterlei, Claudio Festuccia
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
GBM
DNA damage signaling
APIM-peptide
Online Access:https://www.mdpi.com/2072-6694/14/2/289

Internet

https://www.mdpi.com/2072-6694/14/2/289

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