IFN-γ Critically Enables the Intratumoural Infiltration of CXCR3<sup>+</sup> CD8<sup>+</sup> T Cells to Drive Squamous Cell Carcinoma Regression

IFN-γ Critically Enables the Intratumoural Infiltration of CXCR3<sup>+</sup> CD8<sup>+</sup> T Cells to Drive Squamous Cell Carcinoma Regression

Ultraviolet (UV) radiation-induced tumours carry a high mutational load, are highly immunogenic, and often fail to grow when transplanted into normal, syngeneic mice. The aim of this study was to investigate factors critical for the immune-mediated rejection of cutaneous squamous cell carcinoma (SCC...

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Bibliographic Details
Main Authors: Zhen Zeng, Margaret Veitch, Gabrielle A. Kelly, Zewen K. Tuong, Jazmina G. Cruz, Ian H. Frazer, James W. Wells
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
squamous cell carcinoma
IFN-γ
CD8 T cell
regression
immune control
Online Access:https://www.mdpi.com/2072-6694/13/9/2131

Internet

https://www.mdpi.com/2072-6694/13/9/2131

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