Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

Abstract Background Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsib...

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Bibliographic Details
Main Authors: Genevieve Stein-O’Brien, Luciane T. Kagohara, Sijia Li, Manjusha Thakar, Ruchira Ranaweera, Hiroyuki Ozawa, Haixia Cheng, Michael Considine, Sandra Schmitz, Alexander V. Favorov, Ludmila V. Danilova, Joseph A. Califano, Evgeny Izumchenko, Daria A. Gaykalova, Christine H. Chung, Elana J. Fertig
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Genome Medicine
Subjects:
Acquired resistance
Precision medicine
Data integration
Time course analysis
Genomics
Epigenetics
Online Access:http://link.springer.com/article/10.1186/s13073-018-0545-2

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http://link.springer.com/article/10.1186/s13073-018-0545-2

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