Activation of Slit2/Robo1 Signaling Promotes Tumor Metastasis in Colorectal Carcinoma through Activation of the TGF-β/Smads Pathway

Activation of Slit2/Robo1 Signaling Promotes Tumor Metastasis in Colorectal Carcinoma through Activation of the TGF-β/Smads Pathway

Slit2 (slit guidance ligand 2), a ligand of the Roundabout1 (Robo1) transmembrane receptor, is often overexpressed in colorectal carcinomas (CRCs). In this study, we performed data mining in the Metabolic gEne RApid Visualizer (MERAV) database and found that Slit2 and TGF-β1 (Transforming g...

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Bibliographic Details
Main Authors: Yuying Yao, Zijun Zhou, Liuyou Li, Junchen Li, Lixun Huang, Jiangchao Li, Cuiling Qi, Lingyun Zheng, Lijing Wang, Qian-Qian Zhang
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
colorectal carcinoma
metastasis
Slit2/Robo1 signaling
TGF-β/Smads signaling
R5
Online Access:https://www.mdpi.com/2073-4409/8/6/635

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https://www.mdpi.com/2073-4409/8/6/635

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