Modeling the behavior of monoclonal antibodies on hydrophobic interaction chromatography resins

Modeling the behavior of monoclonal antibodies on hydrophobic interaction chromatography resins

Abstract Monoclonal antibodies (mAbs) require a high level of purity for regulatory approval and safe administration. High-molecular weight (HMW) species are a common impurity associated with mAb therapies. Hydrophobic interaction chromatography (HIC) resins are often used to remove these HMW impuri...

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Bibliographic Details
Main Authors: Douglas Nolan, Thomas R. Chin, Mick Eamsureya, Sheldon Oppenheim, Olga Paley, Christina Alves, George Parks
Format: Article
Language:English
Published: SpringerOpen 2024-02-01
Series:Bioresources and Bioprocessing
Subjects:
Bioprocess engineering
Chromatography
Statistical analysis
Bioengineering
Online Access:https://doi.org/10.1186/s40643-024-00738-8

Internet

https://doi.org/10.1186/s40643-024-00738-8

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