The molecular mechanism and challenge of targeting XPO1 in treatment of relapsed and refractory myeloma

Multiple myeloma (MM) treatment regimens have vastly improved since the introduction of immunomodulators, proteasome inhibitors, and anti-CD38 monoclonal antibodies; however, MM is considered an incurable disease due to inevitable relapse and acquired drug resistance. Understanding the molecular mec...

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Bibliographic Details
Main Authors: Mark Sellin, Stephanie Berg, Patrick Hagen, Jiwang Zhang
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Translational Oncology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523322001073