Cabozantinib Inhibits Photodynamic Therapy-Induced Auto- and Paracrine MET Signaling in Heterotypic Pancreatic Microtumors

Cabozantinib Inhibits Photodynamic Therapy-Induced Auto- and Paracrine MET Signaling in Heterotypic Pancreatic Microtumors

Extensive desmoplasia is a hallmark of pancreatic ductal adenocarcinoma (PDAC), which frequently associates with treatment resistance. Recent findings indicate that a combination of photodynamic therapy and the multi-kinase inhibitor cabozantinib achieved local tumor control and a significant decrea...

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Bibliographic Details
Main Authors: Mans Broekgaarden, Ahmed Alkhateeb, Shazia Bano, Anne-Laure Bulin, Girgis Obaid, Imran Rizvi, Tayyaba Hasan
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
pancreatic cancer
photochemotherapy
combination therapy
scatter factor
cancer-associated fibroblasts
cancer stroma signaling
Online Access:https://www.mdpi.com/2072-6694/12/6/1401

Internet

https://www.mdpi.com/2072-6694/12/6/1401

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