Targeting of T Lymphocytes to Melanoma Cells Through Chimeric Anti-GD3 Immunoglobulin T-Cell Receptors

Targeting of T Lymphocytes to Melanoma Cells Through Chimeric Anti-GD3 Immunoglobulin T-Cell Receptors

Immunoglobulin T-cell receptors (IgTCRs) combine the specificity of antibodies with the potency of cellular killing by grafting antibody recognition domains onto TCR signaling chains. IgTCR-modified T cells are thus redirected to kill tumor cells based on their expression of intact antigen on cell s...

Full description

Bibliographic Details
Main Authors: C.O. Yun, K.F. Nolan, E.J. Beecham, R.A. Reisfeld, P. Junghans
Format: Article
Language:English
Published: Elsevier 2000-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
T cell
gene therapy
immunotherapy
signalling
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558600800159

Internet

http://www.sciencedirect.com/science/article/pii/S1476558600800159

Similar Items