Design, pharmacokinetic, and pharmacodynamic evaluation of a lecithin-chitosan hybrid nanoparticle-loaded dual-responsive in situ gel of nebivolol for effective treatment of glaucoma
Abstract In this research work, optimized nebivolol-loaded lecithin-chitosan hybrid nanoparticles (NEB-LCNPs) were prepared using sequential screening and optimization designs. The design of experiments software (DoE) was used to obtain a robust formulation that can improve ocular delivery of the NE...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2024-09-01
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| Series: | Discover Nano |
| Online Access: | https://doi.org/10.1186/s11671-024-04109-2 |