Resveratrol Neuroprotection in a Chronic Mouse Model of Multiple Sclerosis

Resveratrol Neuroprotection in a Chronic Mouse Model of Multiple Sclerosis

Resveratrol is a naturally-occurring polyphenol that activates SIRT1, an NAD-dependent deacetylase. SRT501, a pharmaceutical formulation of resveratrol with enhanced systemic absorption, prevents neuronal loss without suppressing inflammation in mice with relapsing experimental autoimmune encephalom...

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Bibliographic Details
Main Authors: Zoe eFonseca-Kelly, Mayssa eNassrallah, Jorge eUribe, Reas S Khan, Kimberly eDine, Mahasweta eDutt, Kenneth S Shindler
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Neurology
Subjects:
Multiple Sclerosis
Optic Neuritis
Neuroprotection
EAE
resveratrol
SIRT1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2012.00084/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2012.00084/full

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