Inactivation of Magel2 suppresses oxytocin neurons through synaptic excitation-inhibition imbalance

Inactivation of Magel2 suppresses oxytocin neurons through synaptic excitation-inhibition imbalance

Prader-Willi and the related Schaaf-Yang Syndromes (PWS/SYS) are rare neurodevelopmental disorders characterized by overlapping phenotypes of high incidence of autism spectrum disorders (ASD) and neonatal feeding difficulties. Based on clinical and basic studies, oxytocin pathway defects are suggest...

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Bibliographic Details
Main Authors: Tayfun Ates, Merve Oncul, Pelin Dilsiz, Iskalen Cansu Topcu, Cihan Civan Civas, Muhammed Ikbal Alp, Iltan Aklan, Edanur Ates Oz, Yavuz Yavuz, Bayram Yilmaz, Nilufer Sayar Atasoy, Deniz Atasoy
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Neurobiology of Disease
Subjects:
Prader Willi Syndrome
Autism
magel2
Oxytocin
AMPA
NMDA
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118303954

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http://www.sciencedirect.com/science/article/pii/S0969996118303954

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