Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease

Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease

Abstract Background Based on amyloid cascade and tau hypotheses, protein biomarkers of different Aβ and tau species in cerebrospinal fluid (CSF) and blood/plasma/serum have been examined to correlate with brain pathology. Recently, unbiased proteomic profiling of these human samples has been initiat...

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Bibliographic Details
Main Authors: Hong Wang, Kaushik Kumar Dey, Ping-Chung Chen, Yuxin Li, Mingming Niu, Ji-Hoon Cho, Xusheng Wang, Bing Bai, Yun Jiao, Surendhar Reddy Chepyala, Vahram Haroutunian, Bin Zhang, Thomas G. Beach, Junmin Peng
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Biomarker
Cerebrospinal fluid
Brain tissue
Cortex
Blood
Online Access:http://link.springer.com/article/10.1186/s13024-020-00384-6

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http://link.springer.com/article/10.1186/s13024-020-00384-6

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