NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly

NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly

Summary: The α7 nicotinic acetylcholine receptor participates in diverse aspects of brain physiology and disease. Neurons tightly control α7 assembly, which relies upon NACHO, an endoplasmic reticulum (ER)-localized integral membrane protein. By constructing α7 chimeras and mutants, we find that NAC...

Full description

Bibliographic Details
Main Authors: Hae-Jin Kweon, Shenyan Gu, Emily Witham, Madhurima Dhara, Hong Yu, Elodie Desuzinges Mandon, Anass Jawhari, David S. Bredt
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
nicotinic acetylcholine receptor α7
nAChR
NACHO
chaperone
assembly
trafficking
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472031010X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472031010X

Similar Items