Endothelium-protective, histone-neutralizing properties of the polyanionic agent defibrotide

Endothelium-protective, histone-neutralizing properties of the polyanionic agent defibrotide

Neutrophil-mediated activation and injury of the endothelium play roles in the pathogenesis of diverse disease states ranging from autoimmunity to cancer to COVID-19. Neutralization of cationic proteins (such as neutrophil extracellular trap–derived [NET-derived] histones) with polyanionic compounds...

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Bibliographic Details
Main Authors: Hui Shi, Alex A. Gandhi, Stephanie A. Smith, Qiuyu Wang, Diane Chiang, Srilakshmi Yalavarthi, Ramadan A. Ali, Chao Liu, Gautam Sule, Pei-Suen Tsou, Yu Zuo, Yogendra Kanthi, Evan A. Farkash, Jiandie D. Lin, James H. Morrissey, Jason S. Knight
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-09-01
Series:JCI Insight
Subjects:
Inflammation
Vascular biology
Online Access:https://doi.org/10.1172/jci.insight.149149

Internet

https://doi.org/10.1172/jci.insight.149149

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